CELLGEBRA

We are an Irish startup committed to cancer drug discovery

Cellgebra has received significant funding from Enterprise Ireland.  Together with Royal College of Surgeons in Ireland, we are developing a digital solution to aid rational oncology drug discovery. The dominant cause of drug failure (40 to 80%) at clinical trial is inefficacy, which is a result of poor understanding of the molecular mechanisms that cause disease.  Poor understanding leads to incorrect identification of targets and responsive patient populations. Reliable pre-clinical models remain difficult to establish and are expensive for high volume testing. We offer an alternative approach by analysing relevant patient tissue to produce Virtual Tumour Models that can predict the tumour response to a given drug by simulating cell signalling activity of the diseased tissue. Our Virtual Tumour Models enable a wide range of quick and low cost in silico experiments for different patient populations across drug development cycle:

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• identify new drug targets

• test potential drug lead candidates based on specific on and off target profile

• identify responsive patient populations

• identify promising drug combinations

• predict future resistance mechanisms

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The Virtual Tumour Models are produced by using proprietary algorithms to process wetlab datasets generated using patient derived cell lines grown in 3D culture.